2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
PIK-294
CAS: 900185-02-6
Molecular Formula: C28H23N7O2
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one - Names and Identifiers
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one - Physico-chemical Properties
| Molecular Formula | C28H23N7O2 |
| Molar Mass | 489.53 |
| Density | 1.43 |
| Boling Point | 790.4±70.0 °C(Predicted) |
| Appearance | powder |
| Color | white to beige |
| pKa | 8.95±0.10(Predicted) |
| Storage Condition | -20°C |
| Use | PIK-294 is a highly selective p110δ inhibitor with an IC50 of 10 nM. The effect on PI3Kα/β/γ is 1000,49 and 16 times lower, respectively. |
| In vitro study | PIK-294 inhibits different subtypes of PI3K (p110β, p110δ, and p110γ), whereas inhibition of p110α is very selective, with an IC50 of 10 μm. The M-phenol group of PIK-294 is able to penetrate the deep affinity pocket of the ATP binding site, thereby enhancing the inhibitory activity in vitro. |
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.043 ml | 10.214 ml | 20.428 ml |
| 5 mM | 0.409 ml | 2.043 ml | 4.086 ml |
| 10 mM | 0.204 ml | 1.021 ml | 2.043 ml |
| 5 mM | 0.041 ml | 0.204 ml | 0.409 ml |
Last Update：2024-01-02 23:10:35
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one - Reference Information
| biological activity | PIK-294 is a highly selective p110δ inhibitor with an IC50 of 10 nM, the PI3Kα/β/γ effect was 1000,49 and 16 times lower, respectively. |
| features | A p110δ inhibitor. |
Last Update：2024-04-09 20:49:11
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Spot supply
Product Name: PIK-294 Visit Supplier Webpage Request for quotationCAS: 900185-02-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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